The Zarrinpar Lab is interested in the intersection of circadian biology, gut physiology, and the gut microbiome and how the three interact to cause obesity, diabetes, steatohepatitis, and other gut-mediated diseases. We investigate the development of disease as a dynamic process. Specifically, we are interested in the reciprocal interaction between the intestines and their content and how they drive normal gut gene expression, absorption, nutrient sensing, and signaling. When this homeostasis is disturbed, it can affect other target organs. By studying these interactions, we hope to find novel ways to treat difficult diseases.
We are scientists and medical professionals drawn together by the desire to find new ways to fight old diseases.
Antibiotic-induced Microbiome Depletion Alters Metabolic Homeostasis by Affecting Gut Signaling and Colonic Metabolism.
Author(s): Zarrinpar, A., Chaix, A., Chang, M. W., Marotz, C. A., Saghatelian, A., Knight, R., Panda, S.
Source: Nature Communications 9(1): 2872
Diet and Feeding Pattern Affect the Diurnal Dynamics of the Gut Microbiome.
Author(s): Zarrinpar, A., Chaix, A., Yooseph, S., and Panda, S.
Source: Cell Metabolism 20: 1006-1017
Daily Eating Patterns and Their Impact on Health and Disease
Author(s): Zarrinpar, A., Chaix, A., and Panda, S.
Source: Trends in Endocrinology and Metabolism: TEM 27: 69-83
Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigentic Diets in a Randomized Controlled Trial.
Author(s): Frankwich, K.A., Egnatios, J., Kenyon, M.L., Rutledge, T.R., Liao, P.S., Gupta, S., Herbest, K.L., and Zarrinpar, A.
Source: Clinical Gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 13: 1625-1632 e1621